Polycystic ovary syndrome is associated with atherogenic changes in lipoprotein particle number and size independent of body weight
| Autor: | Shwetha Sunghay, Theodore Mazzone, Bert Scoccia, Susan Sam, Chantale N. Stephens-Archer, Seema Sidhwani |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein Triglyceride Endocrinology Diabetes and Metabolism Biology medicine.disease Polycystic ovary Lipoprotein particle chemistry.chemical_compound Endocrinology Sex hormone-binding globulin Insulin resistance chemistry Internal medicine medicine biology.protein lipids (amino acids peptides and proteins) Body mass index Lipoprotein |
| Zdroj: | Clinical Endocrinology. 75:76-82 |
| ISSN: | 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2011.04015.x |
| Popis: | Summary Objective Adverse changes in lipoprotein particle number and size are common with insulin resistance and are associated with increased cardiovascular risk. Comprehensive information regarding lipoprotein particle number and size, and how these parameters relate to body weight, insulin resistance and hyperandrogenemia is lacking in polycystic ovary syndrome (PCOS). We tested the hypothesis that PCOS is associated with atherogenic changes in lipoprotein profile independent of body weight and examined the role of insulin resistance and androgens in these atherogenic changes. Design Case–control study performed at Clinical Research Center at an Academic Medical Center in the United States. Patients and measurements Fasting blood was obtained from 25 PCOS and 25 control women of similar age and body mass index (BMI). Lipoprotein particle number and size was determined by nuclear magnetic resonance and compared between the groups. Results The mean BMI for both groups was |
| Databáze: | OpenAIRE |
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