One-pot embedding of iron oxides and Gd(III) complexes into silica nanoparticles—Morphology and aggregation effects on MRI dual contrasting ability
| Autor: | A. S. Sapunova, Rustem Amirov, Rustem Zairov, Asiya R. Mustafina, Alexey Stepanov, Irek R. Nizameev, Ondrej Kaman, Svetlana V. Fedorenko, Ildus Ismaev, Alexandra D. Voloshina, Kirill V. Kholin, Marsil K. Kadirov |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Morphology (linguistics) biology Doping Relaxation (NMR) Iron oxide Nanoparticle 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Electrokinetic phenomena chemistry.chemical_compound Colloid and Surface Chemistry chemistry Chemical engineering biology.protein Bovine serum albumin 0210 nano-technology Layer (electronics) |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 559:60-67 |
| ISSN: | 0927-7757 |
| Popis: | The present work introduces one-pot synthetic route to join ultra-small iron oxides (6 nm) with Gd(III) complexes in small (∼30 nm) silica nanoparticles with high longitudinal and transverse relaxivity values (r1 = 34.7 mM−1 s−1 and r2 = 64.7 mM−1 s−1 at 0.47 T). The design of the nanoparticles is based on the core-shell morphology, where the Gd(III) complexes were doped into the exterior silica layer. The doping mode is the reason for an efficient interfacial hydration and the small suppressing of r1 by iron oxides. The measurements on the whole body scanner at 1.5 T confirm the high contrasting abilities of T1 (Gd) and T2 (iron oxide) components in the nanoparticles. Poor aggregation behavior of the nanoparticles in water is due to high electrokinetic potential value (−78 mV). Greater aggregation of the nanoparticles in the buffer solutions of bovine serum albumin enhances the disturbing effect of iron oxides on the longitudinal relaxation and facilitates the transverse relaxation. The higher surface activity of the nanoparticles results in their greater cytotoxicity versus the silica coated iron oxides, although the cytotoxicity is low in the concentration range which is within the region of interest for MRI technique. |
| Databáze: | OpenAIRE |
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