| Autor: |
Wilson El, Lisa Oliver, Gillian E. Francis, Eugene B. Dowdle, Patricia E. Burger, Peter Jacobs |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Fibrinolysis. 6:77-79 |
| ISSN: |
0268-9499 |
| Popis: |
The secretion of tissue plasminogen activator (t-PA) and urokinase by normal human bone marrow cells is a differentiation linked property with t-PA being produced by primitive progenitor cells and urokinase being produced by more differentiated cells and by mature neutrophils and macrophages. Cells from patients with acute myeloid leukaemia also secrete both types of plasminogen activator (PA) and the type of enzyme secreted has prognostic significance. Patients whose cells secrete t-PA die rapidly and fail chemotherapy whereas 80% of those individuals whose cells secrete urokinase enter remission following chemotherapy. The generation of plasmin in the haemopoietic microenvironment would influence haemopoiesis by converting precursor cytokines to active species and would also release various haemopoietic cytokines from cell surfaces and matrix facilitating their interaction with cell surface receptors. The inappropriate secretion of PAs by leukaemic cells could result in abnormal haemopoiesis due to the aberrant plasmin-mediated activation and release of various cytokine species. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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