Abstract 1417: Combined Assessment of Left Ventricular Strain and Rotation - A Novel Approach for Assessment of Function in Infarcted Myocardium and its Border Zones

Autor:	Thomas Helle-Valle, Espen Remme, Erik Lyseggen, Trond Vartdal, Eirik Pettersen, Hans Jørgen Smith, Nael F Osman, Ketil Lunde, Thor Edvardsen, Otto A Smiseth
Rok vydání:	2007
Předmět:	Physiology (medical) Cardiology and Cardiovascular Medicine
Zdroj:	Circulation. 116
ISSN:	1524-4539 0009-7322
DOI:	10.1161/circ.116.suppl_16.ii_291-b
Popis:	Background : LV circumferential strain and rotation are markers of myocardial function, but the two measures dissociate in the ischemic LV. This study investigates the mechanism and clinical significance of this dissociation. Methods : In healthy subjects (n=15) and patients with LAD-related myocardial infarction (n=15), LV apical rotation and strain were measured from apical short-axis recordings by STE and MRI tagging. Infarct extent was determined by contrast MRI. To define mechanisms of the dissociation between strain and rotation we used a finite element model. Results : Mean apical rotation and strain by STE were lower in the patients than in healthy subjects (13±4 vs. 10±5° and −24±2 vs. −12±10%, respectively, P P ). The simulation study reproduced the clinical findings and indicated that the dissociation was mainly caused by mechanical interactions between infarcted and viable myocardium transmitted along circumferentially oriented LV fibers. Conclusions : Systolic strain reflects regional myocardial function and infarct extent, while systolic rotation defines infarct borders. Strain and rotation provides complementary information in assessment of myocardial dysfunction and infarct extent.
Databáze:	OpenAIRE
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