Serum concentrations ofl -kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified
| Autor: | Yuhei Shibata, Takuro Matsumoto, Masahito Shimizu, Hisataka Moriwaki, Naoe Goto, Yusuke Kito, Kuniaki Saito, Tatsuhiko Miyazaki, Hiroyasu Ito, Hiroshi Nakamura, Hisashi Tsurumi, Tamotsu Takeuchi, Yasuhito Nannya, Soranobu Ninomiya, Nobuhiko Nakamura, Junichi Kitagawa, Mitsuru Seishima, Takeshi Hara, Tsuyoshi Takami |
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| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
medicine.medical_specialty Vincristine Cyclophosphamide business.industry Pirarubicin Not Otherwise Specified Peripheral T-cell lymphoma not otherwise specified Hematology General Medicine medicine.disease Gastroenterology Peripheral T-cell lymphoma 03 medical and health sciences 0302 clinical medicine International Prognostic Index Endocrinology Oncology 030220 oncology & carcinogenesis Internal medicine medicine Prednisolone business 030215 immunology medicine.drug |
| Zdroj: | Hematological Oncology. 35:637-644 |
| ISSN: | 0278-0232 |
| Popis: | Indoleamine 2,3-dioxygenase exerts intense immunomodulatory effects due to enzymatic activities that catalyze the breakdown of the essential amino acid l-tryptophan. The activity of indoleamine 2,3-dioxygenase can be estimated by measuring serum l-kynurenine concentrations. Here, we aimed to determine the role of l-kynurenine as a prognostic factor for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) in a retrospective analysis of data derived from 31 consecutive patients between June 2000 and March 2013 who were histologically diagnosed with PTCL-NOS according to the World Health Organization classification and treated with 6-8 cycles of cyclophosphamide, doxorubicin or pirarubicin, vincristine, and prednisolone. l-kynurenine concentrations in serum samples collected at admission were measured using high-performance liquid chromatography. The median serum concentration of l-kynurenine was 3.28 (range 0.92-8.16) μM. The l-kynurenine cutoff was set at 3.07 μM using receiver operating characteristics curves. The complete remission rates of patients with l-kynurenine |
| Databáze: | OpenAIRE |
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