Microwave-assisted synthesis and evaluation of naphthalimides derivatives as free radical scavengers

Autor:	Ying-Ming Pan, Qiang Wu, Kai Wang, Ye Zhang, Heng-Shan Wang, Shao-Bo Feng, Xianghui Yi
Rok vydání:	2010
Předmět:	Antioxidant DPPH medicine.medical_treatment Organic Chemistry Naphthalimides chemistry.chemical_compound chemistry medicine Nitro Organic chemistry Moiety General Pharmacology Toxicology and Pharmaceutics Imide Scavenging Naphthalene
Zdroj:	Medicinal Chemistry Research. 20:752-759
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-010-9384-4
Popis:	A facile and efficient microwave-assisted reaction of 1,8-naphthalic anhydride derivatives with primary amines, leading to the synthesis of 1,8-naphthalimides, has been developed. Subsequently, the free radical scavenging properties of the 1,8-naphthalimide derivatives were evaluated against 2,2-diphenyl-1-picrylhydrazyl (DPPH•). The results showed that the scavenging activities of compounds 2a, NBNA, 3b, and 3c were more efficient than that of the common synthetic antioxidant 2,6-diter-butyl-4-methylphenol (BHT), with IC50 values of 61.9, 54.0, 42.2, and 43.1 μM, respectively. The imide groups introduced at position 4 as well as the nitro functionality at position 3 of the naphthalene moiety were the major contributors to the free radical scavenging activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3df1dc99087f4fcfc9fcb7c1b577ee55 https://doi.org/10.1007/s00044-010-9384-4 Zobrazit plný text záznamu Full text from SpringerLink