Effect of monomer composition on the properties of biodegradable poly(NIPAAm-AA-PCLdA) copolymeric hydrogels
| Autor: | Wen-Fu Lee, Tzu-Shen Cheng |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Biodegradable hydrogels
Materials science Polymers and Plastics Monomer composition General Chemistry Surfaces Coatings and Films chemistry.chemical_compound Compressive strength chemistry Chemical engineering Polymer chemistry Self-healing hydrogels Materials Chemistry Drug release medicine Swelling medicine.symptom Caprolactone Acrylic acid |
| Zdroj: | Journal of Applied Polymer Science. 128:230-238 |
| ISSN: | 0021-8995 |
| DOI: | 10.1002/app.38176 |
| Popis: | A series of biodegradable hydrogels were prepared from N-isopropylacrylamide (NIPAAm), acrylic acid (AA), and a biodegradable crosslinker, poly(caprolactone) diacrylate (PCLdA). The effect of the different molar ratios of NIPAAm and AA in the poly(NIPAAm-co-AA) copolymeric hydrogel on the swelling behaviors and physical properties were investigated. The results showed that the swelling ratio in deionized water and in phosphate buffer solution increased with an increase of the content of AA in the copolymeric hydrogel, and the critical gel transition temperature (CGTT) of the copolymeric hydrogel crosslinked with PCLdA was lower than the hydrogel crosslinked with N,N'-methylenebisacrylamide (NMBA). The compressive modulus decreased with an increase of AA content in the copolymeric hydrogels. The gels showed good pH/temperature sensitive behavior. The results also showed that the hydrogel crosslinked with PCLdA has higher crosslinking density (ρx) and higher mechanical strength than the hydrogel crosslinked with NMBA. The influence of the copolymeric composition on the drug release behavior in the poly(NIPAAm-co-AA) hydrogels was also investigated in this study. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 |
| Databáze: | OpenAIRE |
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