Synthesis of canrenone and related steroids labelled with tritium, carbon-14, and sulfur-35
| Autor: | Charles S. Markos, Donald J. Zitzewitz, Clifford R. Dorn |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_treatment
Organic Chemistry Selective catalytic reduction Biochemistry Sodium sulfide Analytical Chemistry Steroid chemistry.chemical_compound chemistry Potassium canrenoate Drug Discovery medicine Spironolactone Organic chemistry Radiology Nuclear Medicine and imaging Carbon-14 Tritium Canrenone Spectroscopy Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 25:515-529 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580250506 |
| Popis: | The synthesis of [1-3H]canrenone, [1-3H]spironolactone, [1-3H]potassium canrenoate, [22-14C]canrenone, [22-14C]spironolactone, [22-14C]potassium canrenoate, and [35S]spironolactone is reported. Tritium labelled compounds were obtained by catalytic reduction of a 3-keto-1,4-diene precursor followed by exchange of enolizable label. Carbon-14 compounds were obtained by reaction of a 17-ethynyl steroid with 14CO2. Sulfur-35 spironolactone was synthesized by the in-situ generation of [35S]thiolacetic acid from [35S]sodium sulfide. |
| Databáze: | OpenAIRE |
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