Synthesis of [5-14C]-1,1,12,12-tetraethoxy-4,9-diazadodecane dinitrate
| Autor: | James P. Demers, Edward E. Knaus, T. W. Hall, Leonard I. Wiebe, Vijayalakshmi V. Somayaji |
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| Rok vydání: | 1989 |
| Předmět: |
Organic Chemistry
ALUMINUM HYDRIDE Inorganic chemistry chemistry.chemical_element Biochemistry Chloride Analytical Chemistry chemistry.chemical_compound chemistry Succinimide Succinic acid Nitric acid Yield (chemistry) Drug Discovery medicine Radiology Nuclear Medicine and imaging Lithium Specific activity Spectroscopy Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 27:449-455 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580270412 |
| Popis: | The reaction of [1-14C]succinyl chloride with 3,3-diethoxypropylamine (4) afforded N,N'-bis(3,3-diethoxypropyl[(1-14C]succinic acid diamide (6, 43.9% chemical and radiochemical yield) and N-(3,3-diethoxypropyl[1-14C]succinimide (7, 35.8% chemical and 35.5% radiochemical yield). Reduction of 6 using lithium aluminum hydride followed by reaction with concentrated nitric acid yielded [5-14C]-1,1,12,12-tetraethoxy-4 9-diazadodecane dinitrate (8) in 16% overall radiochemical yield from [1-14C]succinyl chloride with a specific activity of 55.4 mCi/mmol (2.05 GBq/mmol) and a radiochemical purity of 97.3%. |
| Databáze: | OpenAIRE |
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