Structure–Retention Relationship Study of 2,4-dioxotetrahydro-1,3-thiazole Derivatives
Autor: | Lidija R. Jevrić, Milica Ž. Karadžić, Sanja O. Podunavac Kuzmanović, Eva S. Lončar, Strahinja Z. Kovačević |
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Rok vydání: | 2015 |
Předmět: | |
Zdroj: | Journal of Liquid Chromatography & Related Technologies. 38:1247-1253 |
ISSN: | 1520-572X 1082-6076 |
Popis: | In this paper correlations between molecular lipophilicity of a twelve 2,4-dioxotetrahydro-1,3-thiazole derivatives and their retention characteristics obtained by reversed-phase thin-layer chromatography are presented. The regression models were defined applying two chemometric approaches: linear regression and multiple linear regression. The studied thizole derivatives were described with molecular lipophilicity descriptors that were used for prediction of their retention characteristic RM. Statistically significant and physically meaningful structure–retention relationships were obtained and cross-validated. The predicted results are very well correlated with the experimental data. Very good predictive ability of the established mathematical models allows us to estimate the retention behavior of structurally similar compounds. |
Databáze: | OpenAIRE |
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