Abstract 970: Effect of feeding a high fat, high simple carbohydrate diet on serum prostate specific antigen (PSA) in cynomolgus monkeys

Autor: Magdalena Garcia-Forey, Jeffrey Rogers, Anthony G. Comuzzie, Robert E. Shade, James N. Mubiru, Cassondra Bauer
Rok vydání: 2010
Předmět:
Zdroj: Cancer Research. 70:970-970
ISSN: 1538-7445
0008-5472
DOI: 10.1158/1538-7445.am10-970
Popis: Introduction The prostate specific antigen (PSA) test is used for screening and monitoring of prostate cancer. However, PSA has clinical limitations as it is elevated in other pathological conditions other than prostate cancer. PSA is also influenced by other physiological and environmental variables like genetics and diet. The aim of this study was to investigate the effect of feeding a high fat, high simple carbohydrate (HFHSC) diet on serum PSA in a nonhuman primate species. Methods Fifteen cynomolgus monkeys (Macaca fascicularis) were fed an HFHSC diet for 4 months. Body weight and Dual energy X-ray absorptiometry (DEXA) measurements were done at 0, 8 and 16 weeks. Blood was also drawn from these animals and used to assay serum PSA and serum insulin levels. Results 0 weeks Mean ± SD8 -weeks Mean ± SD16 weeks Mean ± SDP value (0-16) weeksBody weight (kg)5.48 ± 1.095.89 ± 1.355.99 ± 1.440.018Calorie intake (kcal/day)421.8 ± 115.20705.07 ± 101.52684.07 ± 102.361.7 × 10−8Tissue Fat (%)5.57 ± 3.817.29 ± 5.508.04 ± 6.70.155Region fat (%)5.33 ± 3.677 ± 5.237.7 ± 6.480.16Fat (g)289 ± 264.37412.07 ± 375.72467.6 ± 462.890.14Soft tissue mass (g)4860.53 ± 1105.735199.06 ± 1338.795269.33 ± 1435.430.0488Lean mass (g)4571.6 ± 968.114787 ±1125.334801.87 ± 1162.970.056Bone mineral content (g)228.44 ± 44.71234.71 ± 48.74236.85 ± 49.470.031PSA ng/ml0.70 ± 0.570.91 ± 0.460.96 ± 0.620.04Insulin µU/ml14.92 ± 12.1930.87 ± 26.1161.36 ± 66.290.014 Conclusions Feeding cynomolgus monkeys with an HFHSC diet for 4 months resulted in a significant increase in serum PSA levels. The mechanisms underlying this change in serum PSA is still under investigation, however, chronic hyper-insulinemia as indicated in this study might be one of the contributing factors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 970.
Databáze: OpenAIRE