Chronic Cough During Bronchial Asthma
| Autor: | Alessio Fabbrizzi, Guja Bernacchi, Giovanni A. Fontana |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Neurogenic inflammation
medicine.diagnostic_test Eosinophilic bronchitis business.industry medicine.drug_class respiratory system medicine.disease respiratory tract diseases Chronic cough Bronchoalveolar lavage Bronchodilator Immunology Medicine Sputum Bronchoconstriction medicine.symptom business Asthma |
| Zdroj: | Cough: Pathophysiology, Diagnosis and Treatment ISBN: 9783030485702 |
| Popis: | Three subgroups of asthmatic cough are currently recognised: classic asthma, cough variant asthma (CVA) and eosinophilic bronchitis (EB). The prevalence of each of these airway disorders varies worldwide. The common trait of these conditions, in which coughing may be the only or the predominant symptom, is the eosinophilic airway inflammation. The presence of airway hyperresponsiveness differentiates bronchial asthma and CV from EB. In all these conditions, activation of vagally innervated receptors mainly located in the larynx and central airways would be directly responsible for the onset of coughing, while activation of the sensory endings of C-fibres would cause neurogenic inflammation and further stimulation of the receptors through the release of inflammatory mediators. While coughing associated with bronchial asthma or CVA can be suspected on the basis of a positive response to non-specific bronchial challenges, evidence for EB can be sought by performing differential cell counts on samples from sputum induction or bronchoalveolar lavage. An elevated eosinophils (>3%) in the airways in the absence of bronchial hyperreactivity is suggestive for EB. All forms of asthmatic cough respond favourably to steroid treatment with or without bronchodilator therapy. |
| Databáze: | OpenAIRE |
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