Metformin; a mini-review to its antioxidative and anti-inflammatory properties
| Autor: | Sahar Koushki, Amin Hasanvand, Shirin Koushki, Marzieh Eskandarzadeh, Abolfazl Abbaszadeh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
business.industry Urology Glucose uptake Skeletal muscle AMPK Vasodilation Pharmacology medicine.disease Metformin Proinflammatory cytokine 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Insulin resistance Nephrology medicine Endothelial dysfunction business medicine.drug |
| Zdroj: | Journal of Renal Injury Prevention. 7:7-10 |
| ISSN: | 2345-2781 |
| DOI: | 10.15171/jrip.2018.02 |
| Popis: | Metformin, a hypoglycemic drug, increases peripheral glucose uptake, decreases liver glucose production and suppresses insulin resistance in liver and skeletal muscle. The molecular anti-inflammatory mechanism of metformin involves the reduction of the level of proinflammatory cytokines through AMPK activation. It can reduce endothelial dysfunction by ameliorating the expression of inflammatory gene and protein like vascular cell adhesion molecule-1 (VCAM-1), and vasodilating maternal vessels. Many studies showed that AMPK activation were the main contributors to the antioxidant and anti-inflammatory effects of metformin. |
| Databáze: | OpenAIRE |
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