Synthesis and antitumor activity of novel podophyllotoxin derivatives

Autor:	Ming Zhao, Wen Chao Bi, Min Feng, Hong Chen, Shu Fang Bai, Yuan Zhang
Rok vydání:	2009
Předmět:	Antitumor activity Multiple drug resistance chemistry.chemical_compound Podophyllotoxin derivatives Maleic acid chemistry Stereochemistry MTT assay General Chemistry In vitro
Zdroj:	Chinese Chemical Letters. 20:901-904
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2009.03.043
Popis:	In order to find compounds with superior bioactivity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with alcohols through maleic acid and tested against K562 and K562/A02 using MTT assay in vitro .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d90b97b8f239d15a5a78bd2a145f971 https://doi.org/10.1016/j.cclet.2009.03.043 Zobrazit plný text záznamu Full Text from ScienceDirect