A Convenient Synthesis of Chiral Oxazolidin-2-Ones and Thiazolidin-2-Ones and an Improved Preparation of Triphosgene

Autor:	Eliezer Falb, Abraham Nudelman, Alfred Hassner
Rok vydání:	1993
Předmět:	chemistry.chemical_compound Quenching (fluorescence) chemistry Triphosgene Organic Chemistry Condensation Organic chemistry Methanol
Zdroj:	Synthetic Communications. 23:2839-2844
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397919308012605
Popis:	Oxazolidin-2-ones and thiazolidin-2-one are conveniently prepared by condensation of L-serine, L-threonine and L-cysteine, respectively with triphosgene. The corresponding methyl esters may be subsequently obtained by quenching the reaction mixture with methanol, without prior need for the isolation of the free acids. An improved procedure for preparation of triphosgene using an internal cooling system is described.
Databáze:	OpenAIRE
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