Treatment of operable breast cancer in the elderly
| Autor: | Patrick Therasse, R Margreiter, Catherine Legrand, J. van Zijl, Murid A. Chaudary, I Karydas, Ian S. Fentiman |
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| Rok vydání: | 2003 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Proportional hazards model business.industry medicine.medical_treatment Wide local excision Modified Radical Mastectomy medicine.disease Surgery Breast cancer Internal medicine medicine business Radical mastectomy Survival analysis Mastectomy Tamoxifen medicine.drug |
| Zdroj: | European Journal of Cancer. 39:300-308 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/s0959-8049(02)00672-x |
| Popis: | We have examined the outcome of older patients with operable breast cancer treated in a randomised trial by either standard surgery or less extensive surgery and tamoxifen. There were 236 participants aged ⩾70 years, randomised to either modified radical mastectomy MRM ( n =120) or wide local excision (WLE) and tamoxifen (T) 20 mg daily ( n =116). Survival curves were estimated using the Kaplan–Meier method and multivariate analyses were performed using Cox's proportional hazards model. Endpoints were survival and time to first relapse or progression, loco-regional progression, time to distant progression and progression-free survival. No significant difference was seen in terms of progression-free survival, but there were significantly more loco-regional relapses in the WLE+T group. In contrast, there were more distant metastases in the MRM group, but with a similar overall survival in both groups. The results of this trial give cautious support for the use of WLE+T for selected older women. |
| Databáze: | OpenAIRE |
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