MicroRNAs as Potential Therapeutic Targets in Peripheral Arterial Disease

Autor:	Robert M Bernes, Alexis Cunningham, Ayotunde O. Dokun
Rok vydání:	2014
Předmět:	Pathology medicine.medical_specialty Arterial disease Angiogenesis business.industry Ischemia Disease Bioinformatics medicine.disease Peripheral In vivo microRNA Medicine business Perfusion
Zdroj:	International Journal of Diabetology & Vascular Disease Research. :67-70
ISSN:	2328-353X
DOI:	10.19070/2328-353x-1400013
Popis:	Micro RNAs (miRNAs)are small non-coding RNAs that play a role in many biological processes. Many studies have shown that miR- NAs are involved in ischemic conditions and emphasized their role as negative or positive modulators in angiogenesis. In vivo studies using various models bring light to the potential benefits of these miRNAs in perfusion recovery following surgically induced hind limb ischemia (HLI), a model of Peripheral arterial disease (PAD). PAD remains a major healthcare burden, affecting millions of Americans. With little advancement in effective therapy the morbidity and mortality of this disease continues to rise. A better understanding of how miRNAs modulate perfusion recovery may provide a potential effective therapy for PAD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d8af1989d625a20cba9db56158d2807 https://doi.org/10.19070/2328-353x-1400013 Zobrazit plný text záznamu