The Role of Phospholipase in Sperm Physiology and its Therapeutic Potential in Male Infertility
| Autor: | Shoko Tsuji, Akiko Takashima, Kazumi Kishida, Chisako Horikawa, Takashi Murakami, Akiko Nakamura, Shoji Kaku, Jun Kitazawa, Fuminori Kimura, Mika Izuno, Aina Morimune, Akie Takebayashi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Infertility urogenital system Oocyte activation Cell Biology Phospholipase Biology medicine.disease Oocyte Sperm Male infertility Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Human fertilization Reproductive Medicine Capacitation medicine reproductive and urinary physiology |
| Zdroj: | Journal of Mammalian Ova Research. 35:43-52 |
| ISSN: | 1347-5878 1341-7738 |
| DOI: | 10.1274/jmor.35.43 |
| Popis: | In mammals, the role of sperm in the process of fertilization is complex, and several well-defined steps must occur for the sperm to fertilize with the oocyte. Phospholipases (PLs), which regulate the lipid composition of the sperm by hydrolyzation of the phospholipids, are involved in the regulation of the flagellar beat, capacitation, and the acrosomal reaction, as well as in the triggering of the calcium oscillations in the oocyte that lead to oocyte activation. The emerging important role of phospholipases is also revealed by the fact that alterations of sperm lipids can lead to infertility. Phospholipases, especially PLCζ, could represent therapeutic targets to overcome male infertility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|