Multi-functional Fe-Al0.66DTP/MCF catalyst in cascade engineered synthesis of the drug butamben: Novelty of catalyst, reaction kinetics and mechanism
| Autor: | Ganapati D. Yadav, Dipti P. Wagh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Reaction mechanism
Chemical reaction engineering 010405 organic chemistry Chemistry Process Chemistry and Technology 010402 general chemistry Heterogeneous catalysis 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Chemical kinetics Solvent chemistry.chemical_compound Physical and Theoretical Chemistry Butamben Acetonitrile |
| Zdroj: | Molecular Catalysis. 483:110711 |
| ISSN: | 2468-8231 |
| DOI: | 10.1016/j.mcat.2019.110711 |
| Popis: | Cascade engineered synthesis of the drug butamben (n-butyl-p-aminobenzoate), a local anaesthetic, which is used for the treatment of chronic pain, is presented here. A new multifunctional heterogeneous catalyst was synthesized, characterized and used for the direct synthesis of n-butyl-p-aminobenzoate by hydrogenation and esterification. A mixture of p-nitrobenzoic acid, n-butanol, hydrogen, acetonitrile as solvent and catalyst was used and hydrogenated in which hydrogenation precedes esterification. A series of aluminum exchanged dodecatungstophosphoric acids (DTP) (Alx-DTP; x = 0.33–1) (5–20% w/w) supported on mesocellular foam silica (MCF) were prepared. 2% Fe loaded on 15% Al0.66DTP/MCF showed the best activity for one-pot synthesis because the metal and acid sites had proper strength and distribution on MCF. Reaction mechanism and kinetic model were developed. The catalyst 2%Fe-15% Al0.66DTP/MCF was found reusable for four catalytic cycles. This work presents an interesting case of reaction engineering using multi-functional catalyst useful in synthesis of a pharmaceutical drug butamben and has potential applications in other areas. |
| Databáze: | OpenAIRE |
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