Atrial fibrillation is associated with mortality and increased admission biomarkers reflecting neurohormonal activation and inflammation in patients with ST-elevation myocardial infarction

Autor:	M Frydland, J E Moeller, L Holmvang, O K L Helgestad, L O Jensen, J P Goetze, C Hassager
Rok vydání:	2023
Předmět:	General Medicine Cardiology and Cardiovascular Medicine Critical Care and Intensive Care Medicine
Zdroj:	European Heart Journal: Acute Cardiovascular Care. 12
ISSN:	2048-8734 2048-8726 2015-2132
DOI:	10.1093/ehjacc/zuad036.083
Popis:	Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Righospitalets Forskningsfond (07IO) Lundbeck Foundation (R186-2015-2132). Background Neurohormonal activation and inflammation is associated with mortality in STEMI patients. We sought to assess, whether AFIB – a known risk factor in MI – also was associated with increased 1-year mortality as well as neurohormonal activation and inflammation in STEMI patients. Methods In 1892 consecutive STEMI patients from two danish tertiary heart centers biomarkers reflecting neurohormonal activation (copeptin, pro-atrial natriuretic peptide (proANP), and mid-regional pro-adrenomedullin (MRproADM)) and inflammation (ST2) was measured. Patients were stratified according to known AFIB or new onset AFIB on admission vs no AFIB. Results In total, 198 (10%, 100 known/98 new onset) patients had AFIB, which was associated with increased 1-year mortality (19% vs. 8.4%, p Conclusion AFIB in STEMI patients is associated with increased admission biomarkers reflecting neurohormonal activation and inflammation and 1-year mortality.
Databáze:	OpenAIRE
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