A new mixed-ligand Ni(II) complex: crystal structure, protective and anti-inflammatory activity of its nanoparticles on acute viral myocarditis by reducing the release of inflammatory cytokines TNF-α and IL‐1β
| Autor: | W.-X. Huo, D.-S. Bai, X.-T. Liu, Z.-F. Zhang, M. Zhao |
|---|---|
| Rok vydání: | 2020 |
| Zdroj: | Журнал структурной химии. 61:1001-1007 |
| ISSN: | 2542-0976 0136-7463 |
| DOI: | 10.26902/jsc_id50747 |
| Popis: | By means of the mixed-ligand strategy, a new Ni(II)-bearing coordination complex [Ni(pda)(bimb)(H2O)](H2O)1.5 (1, bimb = 6,6'-bis(1H-benzo[d]imidazol-2-yl)-2,2'-bipyridine, H2pda = 4,4'-(pyridine-2,6-diyl)dibenzoic acid) is successfully obtained by the reaction of Ni(NO3)2×6H2O, bimb, and H2pda under hydrothermal reaction conditions. Furthermore, the nanoparticles of 1 (nano 1) with a size distribution of around 160 nm can be produced via a grinding method. In the section of biological research, we describe the anti-inflammatory activity of nano 1 on the acute viral myocarditis model. In the CVB3-induced acute viral myocarditis model, the treatment effect of nano 1 is evaluated by determining the mice survival rate and the CVB3 titer. The anti-inflammatory activity of nano 1 is determined by the ELISA assay of TNF-a and IL-1b levels in plasma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|