N1,N2,N3-Trisisopentenyl Guanidine and N1,N2-Diisopentenyl Guanidine, Two Cytotoxic Alkaloids from Alchornea Cordifolia (Schumach. & Thonn.) Müll. Arg. (Euphorbiaceae) Root Barks
| Autor: | Joëlle Quetin-Leclercq, Sebastien Block, Sara Hoet, Hélène Mavar-Manga, David Chapon, Marie-Claire De Pauw-Gillet |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pharmacology
biology Alchornea cordifolia 010405 organic chemistry Stereochemistry Chemistry Euphorbiaceae Plant Science General Medicine biology.organism_classification 01 natural sciences 0104 chemical sciences HeLa 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Cell culture visual_art Drug Discovery visual_art.visual_art_medium Bark Cytotoxicity Guanidine IC50 |
| Zdroj: | Natural Product Communications. 1:1934578X0600101 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x0600101205 |
| Popis: | This paper describes the purification of two guanidine alkaloids: N1, N2-diisopentenyl guanidine (DIPG) 1 and N1,N2,N3-triisopentenyl guanidine (TIPG) 2 from Alchornea cordifolia root bark and reports their cytotoxic properties on cancer (HeLa, Mel-5, J774) and non cancer (WI 38) cells. TIPG showed the highest cytotoxicity with IC50 values from 0.7 to 14.3 μg/mL (2.6 to 54.3 μM) on the four cell lines while DIPG was much less active: IC50 45.8 and 97.6 μg/mL (234.8 and 500.5 μM) on Mel-5 and HeLa and > 512.8 μM on J774 and WI 38. The results indicate that the cytotoxicity notably decreased with the loss of one isopentenyl substituent. |
| Databáze: | OpenAIRE |
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