Assembly of poly[N-(2-hydroxypropyl)methacrylamide] having cholesteryl moiety as terminal groups

Autor: Ryo Hanamura, Minoru Sugiyama, Kazuo Sugiyama
Rok vydání: 2000
Předmět:
Zdroj: Journal of Polymer Science Part A: Polymer Chemistry. 38:3369-3377
ISSN: 1099-0518
0887-624X
DOI: 10.1002/1099-0518(20000915)38:18<3369::aid-pola150>3.0.co;2-o
Popis: Poly[N-(2-hydroxypropyl)methacrylamide]s (PHPMAs) with one pendant cholesteryl moiety at the polymer end and two pendant cholesteryl moieties at both polymer ends as terminal groups (PHPMA-Chol and PHPMA-2Chol) were prepared by the radical polymerization of N-(2-hydroxypropyl)methacrylamide initiated with 4,4′-azobis-[(3-cholesteryl) 4-cyanopentanoate] in the presence of 2-mercaptoethanol and thiocholesterol as chain-transfer reagents, respectively. The self-organization of the PHPMAs was analyzed by fluorescence and 1H NMR measurements. The critical micelle concentration (CMC) decreases with a decreasing PHPMA degree of polymerization. The CMC of PHPMA-Chol is much larger than that of PHPMA-2Chol. PHPMA exhibits an excellent blood compatibility, as determined from the Michaelis constant for the enzymatic reaction of thrombin and a synthetic substrate, S-2238, in the presence of PHPMA-2Chol. According to a small-angle X-ray scattering measurement, PHPMA-2Chol can hold the cholesterol molecule as a lipophilic drug model in a hydrophobic layer formed by terminal-located cholesteryl groups in PHPMA-2Chol. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 3369–3377, 2000
Databáze: OpenAIRE
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