Wirkung von Etilefrin und Dihydroergotamin auf die Sympathicusaktivität bei Orthostase*

Autor:	Wolfgang Mäurer, Schömig A, U. Spohr, F. Kaden
Rok vydání:	1978
Předmět:	medicine.medical_specialty Cardiac output Sympathetic nervous system Baroreceptor business.industry General Medicine Dihydroergotamine Endocrinology Blood pressure medicine.anatomical_structure Etilefrine Dopamine Internal medicine Anesthesia Heart rate medicine business medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 103:1513-1517
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-0028-1129292
Popis:	Systolic blood pressure, heart rate and concentrations of adrenaline, noradrenaline and dopamine as well as plasma dopamine-beta-hydroxylase (DBH) were measured in 22 subjects in recumbency and on standing up. Six subjects each had previously been given intravenously dihydroergotamine (0.5 mg) or etilefrine (0.25 mg/min) or a placebo. It was demonstrated that orthostasis leads to an increased activity of the sympathetic nervous system and the adrenal system. After administration of dihydroergotamine there was a diminished reaction of the sympathetic nervous system with an increase of venous tone which counteracted the decrease in cardiac output. Etilefrine, on the other hand, inhibited the sympatho-adrenal reaction on orthostasis and decreased the liberation of adrenaline. It acts directly via stimulation of alpha-and beta-receptors and is thus predominantly indicated if there is insufficient response of the baroreceptor reflex at its efferent limb.
Databáze:	OpenAIRE
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