ChemInform Abstract: Synthesis of 5′-C-Branched Thymidines and Conversion to Phosphoramidites

Autor:	Patrick J. Middleton, Guangyi Wang
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Nucleophile Chemistry Nucleic acid General Medicine Thymidine Combinatorial chemistry
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199837255
Popis:	Thymidine was converted to its 5′-epoxy derivative, which was reacted with nucleophiles to give 5′-C-aminomethyl-, 5′-C-bromomethyl-, 5′-C-cyanomethyl, and 5′-C-methoxymethylthymidine derivatives with defined stereochemistry. 5′-C-ally-, 5′-C-hydroxymethyl-, 5′-C-hydroxypropyl-, and 5′-C-(imidazole-4-acetamido)methyl-thymidine derivatives were also prepared. The 5′-C-branched thymidines were converted to the corresponding phosphoramidites.
Databáze:	OpenAIRE
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