Redox-Responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering

Autor:	Liesbeth J. De Cock, Filip Du Prez, Bruno G. De Geest, Wim Van Camp, Tuğba Dışpınar
Rok vydání:	2012
Předmět:	Polymers and Plastics Reducing agent Radical polymerization Bioengineering Biomaterials chemistry.chemical_compound chemistry Chemical engineering Tissue engineering Self-healing hydrogels PEG ratio Materials Chemistry Michael reaction Organic chemistry Amine gas treating Maleimide Biotechnology
Zdroj:	Macromolecular Bioscience. 12:383-394
ISSN:	1616-5187
Popis:	A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Lowmolecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit aninterconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into watersoluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d6c9cf68929cac5a6c94b152143590b https://doi.org/10.1002/mabi.201100396 Zobrazit plný text záznamu Plný text