Abstract P3-10-14: The Prognostic Significance of mib-1 (according to St Gallen Criteria) in Patients (pts) with Early Invasive Breast Cancer (EIBC) and Its Relationship with other Biologic Parameters in a Monoinstitutional Series
| Autor: | Claudio Eccher, L Fasanella, M. Frisinghelli, Mattia Barbareschi, F Berloffa, Enzo Galligioni, Alessia Caldara, Antonella Ferro, R. Triolo, D. Aldovini, Lucia Veronica Cuorvo |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Cancer Research. 70:P3-10 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | PURPOSE: To examine interactions between mib-1 and clinical-pathological markers and their impact on outcomes. PATIENTS AND METHODS: Mib-1 was identified by immunohistochemical staining in 3402 EIBC pts treated from 1995 to 2008. Mib-1 was defined as low (15%), intermediate (16%-30%) and high (>30%) value. Correlation between mib-1 and age, tumor size (T), nodal status (N), ER, PR, HER-2, grading (G) was performed by X2 test. Log-rank test and Cox regression model were performed to test mib-1 as prognostic factor for overall survival (OS) and Disease Free Survival (DFS) and its correlation with other known prognostic factors. RESULTS: Median mib-1 was 25%. Mib-1 was low in 1135, intermediate in 1094 and high in 1173 pts. Median age was 62 years. High mib-1 was significantly (P DFS and OS (P 40 years pts (P25%) resulted a prognostic factor of worse outcome (P CONCLUSIONS: In our experience, Mib-1 confirms to be a significant prognostic biomarker for DFS and OS in EIBC, providing additional information besides other clinico-pathological parameters to help decision-making of treatment. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-10-14. |
| Databáze: | OpenAIRE |
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