Inhibition of Fibrinolysis in the Burned-Infected Rat: Antiplasmin Induced by Burn Wound Infection

Autor:	J. P. Baron, D. D. McEuen, Lindberg Rb, W. A. Andes
Rok vydání:	1976
Předmět:	medicine.medical_specialty Burn wound business.industry medicine.medical_treatment Anesthesia Fibrinolysis medicine Hematology business Surgery
Zdroj:	Thrombosis and Haemostasis. 36:173-181
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1648022
Popis:	SummaryInfection is the leading cause of death in the burned patient. To study the effects of uncomplicated and lethally-infected burn wounds on certain hematologic indices, a dorsal scald burn was administered to 250 rats. One group was then infected with Pseudomonas aeruginosa. These rats expired within 10 days. A burned, uninfected, group survived. Sequential determinations were made of fibrinogen, fibrinolysis, antiplasmins, plasminogen antiactivators, cultures, and autopsy findings.Fibrinogen concentrations were higher in the infected animals within 2 days postbum and at day 3 (p The cause of these findings remains unknown. The marked fall in plasminogen in the infected animals may be entirely due to unneutralized antiplasmin activity and was coincident with a decline in fibrin-related antigens. These antiplasmins may exert deleterious effects on microcirculatory dynamics and were closely linked to the animals’ demise.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d61feb304d60bd523d927379483d67f https://doi.org/10.1055/s-0038-1648022 Zobrazit plný text záznamu