Hematopoietic organs of mice after a single injection oxyhydrocortisone

Autor:	V. V. Portugalov, V. N. Shvets
Rok vydání:	1979
Předmět:	education.field_of_study Population Spleen General Medicine Biology General Biochemistry Genetics and Molecular Biology Andrology Haematopoiesis medicine.anatomical_structure Lymphatic system Immunology medicine Cytotoxic T cell Bone marrow Stem cell education Hormone
Zdroj:	Bulletin of Experimental Biology and Medicine. 87:12-16
ISSN:	1573-8221 0007-4888
Popis:	The method of exogenous cloning of hematopoietic stem cells (colony-forming units-CFU) in the spleen and bone marrow of lethally irradiated recipients was used to study the population kinetics and direction of differentiation of CFU from mice receiving a single dose (5 mg per mouse) of hydrocortisone. Against the background of prolonged involution of the lymphoid tissue changes took place in the population and differentiation of CFU. Meanwhile the CFU concentration in the spleen and femoral bone marrow of the mice remained constant. After administration of the hormone, the powers of differentiation of CFU from spleen and bone marrow changed sharply in opposite directions: Marrow CFU behaved like splenic CFU whereas splenic CFU behaved like marrow CFU of normal mice. It is suggested that these effects are due to redistribution of T lymphocytes and not to the direct cytotoxic action of hydrocortisone on the CFU population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d558d95cd97fa631120a85932be4361 https://doi.org/10.1007/bf00802341 Zobrazit plný text záznamu Full text from SpringerLink