Tritiation of the botanically derived toxin dihydrorotenone
| Autor: | Judith A. Egan, Crist N. Filer |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Toxin
Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Rotenone Biology medicine.disease_cause Pollution Rotenoid Analytical Chemistry chemistry.chemical_compound Nuclear Energy and Engineering chemistry Dihydrorotenone Biochemistry High specific activity medicine Radiology Nuclear Medicine and imaging Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 329:1067-1071 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-021-07852-3 |
| Popis: | Pests such as insects threaten the efficient production of the world’s demanding food requirements. For this reason, insect management has increasingly relied on botanical insecticides as safer alternatives to synthetic agents. Rotenone and related compounds (rotenoids) were among the earliest botanical natural products to be identified as useful insecticides. To elucidate the rotenoid mechanism of action at the insect receptor level and design even more effective insecticides, a tritiated rotenoid analogue was required. As a result, this paper describes the successful synthesis and characterization of [3H] dihydrorotenone at high specific activity. In doing so, it also provides another example of a tritiated dihydro analogue of a parent compound acting as a surrogate for it in biological applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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