ChemInform Abstract: Redox-Triggered α-C-H Functionalization of Pyrrolidines: Synthesis of Unsymmetrically 2,5-Disubstituted Pyrrolidines

Autor:	Hao-Jie Rong, Jun-Jun Yao, Jin Qu, Yong-Feng Cheng, Cheng-Bo Yi
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Nucleophile Stereochemistry Chemistry Intermolecular force Substituent Surface modification General Medicine Cleavage (embryo) Redox Pyrrole derivatives
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201608131
Popis:	By using o-benzoquinone as an internal oxidant, the regio- and diastereoselective functionalization of the secondary over the tertiary α-C–H bond of 2-substituted pyrrolidines is first realized. Subsequent intermolecular addition of a nucleophile to the generated N,O-acetal and cleavage of the aromatic substituent leads to 2,5-disubstituted pyrrolidines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d4f15dff2dc942abbca116488f8aad2 https://doi.org/10.1002/chin.201608131 Zobrazit plný text záznamu Plný text