Feedback Actions of Adrenal Steroid Hormones
| Autor: | U. Beckford, M.C. Holmes, B. Gillham, M. T. Jones, B.D. Greenstein |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
endocrine system
medicine.medical_specialty Hypophysectomy business.industry Adrenal cortex medicine.medical_treatment medicine.disease medicine.anatomical_structure Endocrinology Atrophy Anterior pituitary Zona glomerulosa Internal medicine medicine Secretion Cortisone business Hormone medicine.drug |
| Zdroj: | Current Topics in Neuroendocrinology ISBN: 9783642683381 |
| DOI: | 10.1007/978-3-642-68336-7_3 |
| Popis: | The earliest work on the ways in which corticosteroids might influence the functional activity of the pituitary adrenocortical system was reported by Ingle and Kendall (1937). They showed that the administration of adrenocortical extracts to intact rats resulted Departments of Physiology, Biochemistry1, and Pharmacology2, St. Thomas’s Hospital Medical School, Lambeth Palace Road, London SEI 7EH, Great Britain in adrenocortical atrophy, whilst the simultaneous injection of an anterior pituitary extract with that from the adrenal cortex prevented the atrophic response (Ingle and Kendali 1937; Ingle et al. 1938). Subsequently, Deane and Greep (1946) showed that hypophysectomy results in atrophy of the zonae fasiculata and reticularis but the zona glomerulosa was virtually unaffected. A similar histologic picture was described by Winter et al. (1950) following prolonged treatment with Cortisone. Their results suggested that corticosteroid treatment inhibits adrenocorticotrophin (ACTH) secretion and the possibility that ACTH secretion could be regulated by adrenocortical secretions. |
| Databáze: | OpenAIRE |
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