Thermal Rheological Analysis of Triethanolamine-Stearate Stabili Zed Mineral Oil in Water Emulsions

Autor:	R. G. Hollenbeck, F. Fong-Spaven
Rok vydání:	1986
Předmět:	Pharmacology Continuous measurement Liquid crystalline Chemistry Organic Chemistry Pharmaceutical Science Mineralogy TRIETHANOLAMINE STEARATE Constant rate Chemical engineering Rheology Drug Discovery Thermal Emulsion medicine Mineral oil medicine.drug
Zdroj:	Drug Development and Industrial Pharmacy. 12:289-302
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639048609026615
Popis:	Thermal Theological analysis (TRA) is employed as an analytical method to quantitatively assess temporal viscosity changes in triethanolamine-stearate stabilized mineral oil/water systems. Continuous measurement of stress required to maintain a constant rate of shear was monitored while temperature was raised from 25 to 75°C. The rheological profiles obtained were distinquished by distinct, unexpected, reproducible discontinuities which were formulation dependent and changed with time and temperature. These changes have been attributed to as yet unverified shifts in individual and aggregate liquid crystalline structures. Quantitative analysis studies currently underway will aid in determining the usefulness of thermal Theological data as a predictive tool of long term emulsion stability.
Databáze:	OpenAIRE
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