Highly regioselective dipolar cycloadditions of nitrile oxides with α,β-acetylenic aldehydes

Autor:	Jian Wang, Haibing Guo, Yalan Xing, Tao Gao, Zhi Li, Longqiang Jiang, Shaofa Sun, Changfeng Huang, Claudia Kim
Rok vydání:	2016
Předmět:	Nitrile 010405 organic chemistry Organic Chemistry Regioselectivity Substrate (chemistry) 010402 general chemistry 01 natural sciences Biochemistry Cycloaddition 0104 chemical sciences chemistry.chemical_compound chemistry Reagent Drug Discovery Functional group Organic chemistry Amine gas treating
Zdroj:	Tetrahedron Letters. 57:712-714
ISSN:	0040-4039
Popis:	1,2-Oxazol derivatives 3 were prepared by a highly regioselective 1,3-dipolar cycloaddition of nitrile oxides and α,β-acetylenicaldehydes 1 in good yields. Reactive nitrile oxides were generated in situ from stable chloro-oxime reagents 2 and triethyl amine. The cycloaddition reaction showed broad substrate scope and good functional group compatibility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d4376d3da660a948d9f8d7508b5f979 https://doi.org/10.1016/j.tetlet.2016.01.019 Zobrazit plný text záznamu Full Text from ScienceDirect