Double Ablative Chemotherapy with Autologous Marrow Rescue in the Treatment of Acute Leukaemia

Autor:	C. C. Anderson, J. C. Cawley, J. D. M. Richards, D. C. Linch, M. Jones, S. P. Closs, A. H. Goldstone
Rok vydání:	1984
Předmět:	medicine.medical_specialty Chemotherapy Autologous marrow Marrow transplantation business.industry medicine.medical_treatment First remission Early Relapse Aplasia medicine.disease Minimal residual disease Surgery Ablative case medicine business
Zdroj:	Minimal Residual Disease in Acute Leukemia ISBN: 9789401090025
DOI:	10.1007/978-94-009-5670-4_22
Popis:	Seventeen patients with acute leukaemia (8 AML and 9 ALL) have entered a trial protocol involving two courses of ablative chemotherapy followed by rescue with autologous bone marrow transplantation (ABMT). The treatment was generally well tolerated and only one patient died during the period of marrow aplasia. Only one of the 10 patients receiving ablative chemotherapy with ABMT after first remission has survived for a prolonged period. This patient completed the double ABMT procedure and is well at 538 days. Among first remission patients, there has been only one early relapse (Thy-ALL), and the others are well at 60–960 days. Double ablative chemotherapy with ABMT may be useful in reducing minimal residual disease, thereby prolonging first remission in adult acute leukaemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d41c8d0b945f93a8836744d08121984 https://doi.org/10.1007/978-94-009-5670-4_22 Zobrazit plný text záznamu