| Autor: |
Cathy Davies, Daniel Martins, Ottavia Dipasquale, Robert A. McCutcheon, Andrea De Micheli, Valentina Ramella-Cravaro, Umberto Provenzani, Grazia Rutigliano, Marco Cappucciati, Dominic Oliver, Steve Williams, Fernando Zelaya, Paul Allen, Silvia Murguia, David Taylor, Sukhi Shergill, Paul Morrison, Philip McGuire, Yannis Paloyelis, Paolo Fusar-Poli |
| Rok vydání: |
2023 |
| Popis: |
Abnormalities in functional brain networks (functional connectome) are increasingly implicated in people at Clinical High Risk for Psychosis (CHR-P). Intranasal oxytocin, a potential novel treatment for the CHR-P state, modulates network topology in healthy individuals. However, its connectomic effects in people at CHR-P remain unknown. Forty-seven men (30 CHR-P and 17 healthy controls) received acute challenges of both intranasal oxytocin 40 IU and placebo in two parallel randomised, double-blind, placebo-controlled cross-over studies. Multi-echo resting-state fMRI data was acquired at approximately 1h post-dosing. Using a graph theoretical approach, the effects of group (CHR-P vs healthy control), treatment (oxytocin vs placebo) and respective interactions were tested on graph metrics describing the topology of the functional connectome. Group effects were observed in 12 regions (all pFDRFDRFDR |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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