Synthesis and Antimicrobial Evaluation of Pyrazole-4-carboxamide Derivatives

Autor:	Shameem Sultana, Rangapuram Vasanthi
Rok vydání:	2022
Předmět:	General Chemistry
Zdroj:	Asian Journal of Chemistry. 34:2222-2226
ISSN:	0975-427X 0970-7077
DOI:	10.14233/ajchem.2022.23834
Popis:	Microbial resistance to the clinically employed antibiotics becomes a threat to the treatment protocols of microbial infectious diseases. Current work aims to synthesize a novel series of pyrazole-4- carboxamide derivatives (6a-j) in a multicomponent reaction between 1H-pyrazole-4-cabaldehyde and various substituted anilines in the presence of 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (iPr)/TEMPO/phenol under oxidative amidation condition. All the synthesized derivatives (6a-j) were examined for their antifungal and antibacterial activities. All compounds (6a-j) showed significant antimicrobial potential against Gram-positive bacteria (B. subtilis and S. aureus), Gram-negative bacteria (E. coli and P. seruginosa) and fungal strains (A. niger and C. albicans). Compounds 6a, 6f and 6g exhibited better antimicrobial activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d3c1b89296f36b426978df208d95479 https://doi.org/10.14233/ajchem.2022.23834 Zobrazit plný text záznamu