Hepatitis A-associated cholestasis and aplastic anemia

Autor:	Zinab Ashour Saad, Fauzi Abdalla Sagher, Amal Salem Elarabi
Rok vydání:	2019
Předmět:	medicine.medical_specialty Sickle cell trait medicine.diagnostic_test business.industry viruses Fulminant Hepatitis A medicine.disease Gastroenterology Cholestasis Internal medicine medicine Aplastic anemia ABCB11 Complication Liver function tests business
Zdroj:	Ibnosina Journal of Medicine and Biomedical Sciences. 11:188-191
ISSN:	1947-489X
DOI:	10.4103/ijmbs.ijmbs_53_19
Popis:	Hepatitis A virus (HAV) infection in children is typically an acute, self-limited illness associated with general, nonspecific symptoms. Prolonged cholestasis is a rare atypical form of HAV infection that is characterized by serum bilirubin levels higher than 10 mg/dl for more than 12 weeks. Aplastic anemia is another very rare complication of HAV. We report the case of an 11-year-old male with blood group O Rh positive who developed cholestasis followed by aplastic anemia postfulminant HAV infection. Liver function tests rapidly responded to a short course of steroid treatment. The patient had a sickle cell trait and a variant of ABCB11 gene. There was no history of traditional herbal treatment, but we noticed several cautery marks. Immunosuppressive medication was started for aplastic anemia, and he is listed for urgent bone marrow transplant. This is the first reported case of prolonged cholestasis followed by aplastic anemia complicating fulminant HAV infection in a Libyan adolescent.
Databáze:	OpenAIRE
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