Decreased dihydromorphine and D-ala2-D-leu5-enkephalin binding after dynorphin pretreatment in mice
| Autor: | Ming-Feng Jen, Nancy M. Lee, Javier Garzón |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Enkephalin Chemistry musculoskeletal neural and ocular physiology Dihydromorphine General Medicine Dynorphin General Biochemistry Genetics and Molecular Biology In vitro Endocrinology nervous system In vivo Internal medicine polycyclic compounds medicine General Pharmacology Toxicology and Pharmaceutics Opiate medicine.drug |
| Zdroj: | Life Sciences. 31:1813-1816 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(82)90217-x |
| Popis: | Dynorphin(1–13) has been shown to antagonize morphineinduced analgesia and to inhibit opiate receptor binding in vitro . In this study, we pretreated mice with dynorphin; opiate receptor binding was then performed in crude P 2 fractions in vitro , using radioactive dihydromorphine and D-ala 2 -D-leu 5 -enkephalin. It was found that both dihydromorphine and D-ala 2 -D-leu 5 -enkephalin binding were significantly decreased by in vivo dynorphin treatment. Dynorphin's effect was both dose- and time-dependent; maximum effects were obtained at 30', lasted up to 3 hrs and were fully recovered by 12 hrs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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