| Autor: |
Carmelo Giordano, Bello P, D Cirillo, Pluvio M, L Calabria, Lanzetti N, Esposito R, Quarto E |
| Rok vydání: |
2015 |
| Předmět: |
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| DOI: |
10.1159/000406180 |
| Popis: |
Hemoperfusion on ionic exchange resins in the therapy of diabetic keto-acidosis (DKA) coma is proposed. Resins used are strong anionic resins in mixed form able to release bicarbonates and to trap ketoanions and organic anions in a stoichiometric manner. A series of trials in open circuit are performed in order to search for a suitable mixture of resins and to establish the amounts of HCO3- and ketoanions respectively released or entrapped. Therefore, ten simulated hemoperfusions in closed circuit systems were performed, utilizing cartridges containing 1,700 g of mixed resin (9% HCO3- form and 91% Cl- form). The results indicate that all side effects of bicarbonate i.v. therapy of DKA coma are avoided because of the smooth HCO3- administration to the patient. Furthermore, a good removal of ketoanions and organic acids is obtained without changing the blood osmolality. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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