DioRaSSP: Diosynth Rapid Solution Synthesis of Peptides

Autor:	Frits T. Bakelaar, Ivo Franci Eggen, and Annet Petersen, Paul B. W. Ten Kortenaar
Rok vydání:	2005
Předmět:	Fully automated Chemistry Homogeneous business.industry Yield (chemistry) Organic Chemistry Nanotechnology Solution synthesis Physical and Theoretical Chemistry business Biological system Automation
Zdroj:	Organic Process Research & Development. 9:98-101
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op049864l
Popis:	We have developed a novel method for the large-scale manufacturing of peptides in solution called DioRaSSP. It combines the advantages of the homogeneous character of classical solution-phase synthesis with the generic character and the amenability to automation inherent to the solid-phase approach. DioRaSSP is characterized by the fact that intermediates are not isolated. Processes according to this highly efficient synthesis method are easy to scale-up and yield products of reproducible high purity. Moreover, we have recently implemented the first fully automated solution-phase peptide synthesizer for application in processes according to DioRaSSP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3d1d3cefc6475b6a10f163226050258a https://doi.org/10.1021/op049864l Zobrazit plný text záznamu