Sialyl Lex and Sialyl Lea Expression in Human Extrahepatic Bile Duct Adenocarcinoma
| Autor: | Toshihide Imaizumi, Makiko Tanaka, Hiroshi Kijima, Sadaki Inokuchi, Kosuke Tobita, Shoichi Dowaki, Yasuo Ohtani, Hiroyasu Makuuchi, Hiroyuki Kashiwagi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
Pathology medicine.medical_specialty Stromal cell Chemistry Sialyl Lex General Medicine medicine.disease Molecular biology General Biochemistry Genetics and Molecular Biology Sialyl LeA Metastasis carbohydrates (lipids) Antigen embryonic structures Cancer cell cardiovascular system medicine Extrahepatic Bile Duct Adenocarcinoma Glycoprotein |
| Zdroj: | Biomedical Research. 24:277-283 |
| ISSN: | 1880-313X 0388-6107 |
| Popis: | Sialyl Le x (FH6) and sialyl Le a (CA19-9) antigens, members of a family of high molecular weight glycoproteins, are ligands for E-selectin and may play important roles in tumor metastasis. However, expression patterns ofsialyl Le x and sialyl Le a have not been established in human extrahepatic bile duct cancer. In this study, we examined sialyl Le x and Le a expression in human extrahepatic bile duct adenocarcinoma and their clinicopathological significance. Sialyl Le x immunoreactivity was detected not only in cancer cells (cytoplasmic type; 57.7%, 30/52), but also in cancer stroma (stromal type; 19.2%, 10/52). Sialyl Le a immunoreactivity was found in cancer cells (cytoplasmic type; 84.6%, 44/52) and in cancer stroma (stromal type; 63.5%, 33/52). Stromal sialyl Le a expression was more frequent than stromal sialyl Le x expression (p |
| Databáze: | OpenAIRE |
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