Permissive Hypercapnia in Neonates
| Autor: | Waldemar A. Carlo, J. Davin Miller |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Lung
business.industry Retrospective cohort study respiratory system Lung injury medicine.disease respiratory tract diseases Respiratory acidosis medicine.anatomical_structure Bronchopulmonary dysplasia Permissive hypercapnia Anesthesia Pediatrics Perinatology and Child Health medicine medicine.symptom business Hypercapnia Tidal volume circulatory and respiratory physiology |
| Zdroj: | NeoReviews. 8:e345-e353 |
| ISSN: | 1526-9906 |
| Popis: | Permissive hypercapnia, involving the acceptance of higher values of arterial CO2 tension (Paco2) while using lower tidal volumes, may reduce the risk of lung injury. Animal models and in vitro experimental data suggest that hypercapnia may enhance host defense mechanisms in preterm lungs through anti-inflammatory and immune-modulating mechanisms. Retrospective studies in neonates have documented the association of higher Paco2 with less lung injury. Randomized clinical trials have shown a decreased need for assisted ventilation and a trend toward a lower incidence of bronchopulmonary dysplasia or death with permissive hypercapnia. Continued research is needed to determine the appropriate clinical application of permissive hypercapnia, the optimal level of hypercapnic acidosis, and the safety of the therapy in preterm infants. |
| Databáze: | OpenAIRE |
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