Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity
| Autor: | Elena V. Shmendel, T. S. Kubasova, D. K. Shishova, Alexander A. Shtil, Mikhail A. Maslov, K. A. Perevoshchikova, L. L. Tyutyunnik, Nina G. Morozova |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Antitumor activity 010405 organic chemistry Stereochemistry Cationic polymerization General Chemistry Carbohydrate 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Yield (chemistry) Moiety Glycosyl Cytotoxicity Alkyl |
| Zdroj: | Russian Chemical Bulletin. 64:1648-1654 |
| ISSN: | 1573-9171 1066-5285 |
| DOI: | 10.1007/s11172-015-1055-7 |
| Popis: | New non-phosphorous carbohydrate-containing cationic alkyl glycerolipids bearing a ter- minal glycosyl moiety were synthesized. An approach used for the preparation of 2-O-ethyl-1-O-octadecyl-rac-glycerol allowed us to increase the yield of this key precursor by a factor of two. The carbohydrate-containing cationic alkyl glycerolipids induced tumor cell death and minimal damage to normal cells (in particular, erythrocytes), which makes the new compounds promising for practical purposes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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