Synthesis of N-kojic-amino acid and N-kojic-amino acid-kojiate and their tyrosinase inhibitory activity
| Autor: | Yuka Kobayashi, Koji Tadasa, Hiroshi Kayahara, Hidenori Tanaka |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
Chemistry Stereochemistry Tyrosinase Organic Chemistry Clinical Biochemistry Pharmaceutical Science Inhibitory postsynaptic potential Biochemistry Amino acid Inhibitory potency chemistry.chemical_compound Drug Discovery Molecular Medicine Kojic acid Molecular Biology IC50 |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:1303-1308 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(96)00221-1 |
| Popis: | Ten amino acid derivatives of kojic acid were synthesized to improve the tyrosinase inhibitory activity of kojic acid. Almost all derivatives showed stronger activities than kojic acid, and in general, N-kojic-amino acid-kojiate was found to have a higher inhibitory potency than N-kojic-amino acid. Among them, the N-kojic-L-phenylalanyl kojiate was the strongest inhibitor and its IC50 value was 1/380 that for kojic acid. The inhibition mechanism of these derivatives is considered to be noncompetitive which is similar to that of kojic acid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect