Iron-sulfur cluster 3 of beef heart succinate-ubiquinone oxidoreductase is a 3-iron cluster
| Autor: | Helmut Beinert, Brian A. C. Ackrell, W B Mims, Edna B. Kearney, Jack Peisach |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
chemistry.chemical_classification
Oxidative degradation Chemistry Iron–sulfur cluster Cell Biology Biochemistry law.invention chemistry.chemical_compound Crystallography Nuclear magnetic resonance law BEEF HEART Oxidoreductase Electric field Succinate Ubiquinone Oxidoreductase Cluster (physics) Electron paramagnetic resonance Molecular Biology |
| Zdroj: | Journal of Biological Chemistry. 259:4015-4018 |
| ISSN: | 0021-9258 |
| DOI: | 10.1016/s0021-9258(17)43000-6 |
| Popis: | From a study of the magnetic field dependence of the linear electric field effect (LEFE) in EPR spectroscopy, we demonstrate that iron-sulfur cluster 3 in air-oxidized, beef heart succinate-ubiquinone oxidoreductase (Complex II) is a 3-iron cluster. This suggests that cluster 3 may arise by oxidative degradation from a 4-iron cluster originally present in the enzyme and may be reconverted back into a 4-iron cluster under reducing conditions. Linear electric field effect studies of succinate-reduced Complex II are in accord with the view that cluster 1 is a 2-iron cluster. |
| Databáze: | OpenAIRE |
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