Rs10757274 gene polymorphisms in coronary artery disease
| Autor: | Li Yuan, Yafeng Zhou, Lu Chen, Nan-Nan Zhang, Xi Wang, Yi-Qing Zhang, Zhen Han, Xiao-Yang Li, Biao Li, Xuexing Ma, Jia-Yi Weng, Lang-Biao Xu, Guidong Xu, Pei-Ran Yu, Hong-Tao He, Wen-Chao Lu |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Locus (genetics) Heterozygote advantage General Medicine Odds ratio medicine.disease Confidence interval Coronary artery disease 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Meta-analysis medicine SNP 030212 general & internal medicine Allele business |
| Zdroj: | Medicine. 99:e18841 |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000018841 |
| Popis: | BACKGROUND It has been reported the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2BAS1) might be associated with susceptibility to coronary artery disease (CAD). Owing to mixed and inconclusive results, we conducted a meta-analysis to investigate the association between rs10757274 polymorphism and the risk of CAD. OBJECTIVES The present study aimed to investigate the relationship between rs10757274 polymorphism and the risk of CAD. METHODS All studies of the rs10757274 SNP with CAD that were published between 2007 and 2018 were retrieved from the PubMed database. Meta-analysis was performed with Stata 14.0 software. The effect size of the rs10757274 SNP with CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI). RESULTS Eleven studies including 52,209 subjects (cases: 7990, controls: 44,219) were included in the final data combination. Pooled overall analyses showed that rs10757274 (allele model: P |
| Databáze: | OpenAIRE |
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