Production of Immunity to Poliomyelitis Virus in Motor Cells of the Monkey's Spinal Cord

Autor:	David Bodian, Howard A. Howe
Rok vydání:	1939
Předmět:	Pathology medicine.medical_specialty business.industry Leg paralysis Spinal cord Virology General Biochemistry Genetics and Molecular Biology Greater sciatic notch Poliomyelitis virus medicine.anatomical_structure Immunity medicine Nasal administration Sciatic nerve business Nerve section
Zdroj:	Experimental Biology and Medicine. 42:346-349
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-42-10902
Popis:	The following experiments constitute a demonstration that, as in the case of the olfactory bulbs already reported,1certain motor cells in the spinal cord of the rhesus monkey may be rendered resistant to the effects of invasion by poliomyelitis virus by means of procedures which produce alterations in their normal metabolism. Eighteen animals were subjected to section of the sciatic nerve in the sciatic notch at intervals varying between 3 and 57 days previous to the induction of complete leg paralysis by intranasal inoculation of poliomyelitis virus. A series of 6 uninoculated controls were operated upon in a similar fashion and sacrificed at intervals between 6 and 30 days.These animals may be grouped under two headings. The first includes those monkeys in which the nerve section either produced no effect upon the susceptibility of the cells involved, or may have slightly enhanced it. This situation was found in 3 cases where nerve section had preceded leg paralysis by 3-4 days. In this group the cells ...
Databáze:	OpenAIRE
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