Thermal Stability of Primary S-Nitrosothiols: Roles of Autocatalysis and Structural Effects on the Rate of Nitric Oxide Release

Autor:	Nelson H. Morgon, Marcelo Ganzarolli de Oliveira, and Amedea B. Seabra, Silvia Mika Shishido
Rok vydání:	2002
Předmět:	Autocatalysis chemistry.chemical_compound Aqueous solution Primary (chemistry) Chemistry Inorganic chemistry Kinetics Thermal stability Physical and Theoretical Chemistry Decomposition Nitric oxide S-Nitrosothiols
Zdroj:	The Journal of Physical Chemistry A. 106:8963-8970
ISSN:	1520-5215 1089-5639
DOI:	10.1021/jp025756u
Popis:	S-Nitrosothiols (RSNOs) are considered to play important roles in storing, transporting, and releasing nitric oxide (nitrogen monoxide, NO) in vivo. Although tertiary RSNOs are known to be intrinsically more stable than primary RSNOs, the correlation between the structure of primary RSNOs and the kinetics of thermal NO release in solution has not been established yet. We have characterized the kinetics of thermal NO release from three primary RSNOs: S-nitrosocysteine (CySNO), S-nitroso-N-acetylcysteine (SNAC), and S-nitrosoglutatione (GSNO) in aqueous solutions. It was found that the rates of NO release are strongly affected by the initial concentration of the solutions. Increasing the concentration of CySNO and SNAC from 1.0 × 10-1 to 61.0 mmol L-1 led to 5.7- and 14.6-fold increases in their initial rates of decomposition, respectively, whereas GSNO was much less affected (a 2-fold increase). However, a smaller increase in concentration (0.1 to 1.0 mM) led to a 4.6-fold decrease, on average, in the rat...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3cff5914dacabdd76a96e685680e47cc https://doi.org/10.1021/jp025756u Zobrazit plný text záznamu