Studies on the sulfur-containing chelating agents. XLIV. Kinetic study of ligand exchange reaction of mercury-aminopolycarboxylate with monothiodibenzoylmethane by solvent exttraction method

Autor:	Akira Yokoyama, Nobuko Nakanishi, Hisashi Tanaka
Rok vydání:	1975
Předmět:	Reaction mechanism Chromatography Chemistry Inorganic chemistry Aqueous two-phase system General Chemistry General Medicine Rate-determining step Dissociation (chemistry) Reaction rate chemistry.chemical_compound Reaction rate constant Drug Discovery Chelation Aminopolycarboxylic acid
Zdroj:	Chemical and Pharmaceutical Bulletin. 23:1677-1683
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.23.1677
Popis:	The kinetics of ligand exchange reaction of mercury-aminopolycarboxylates (Hg-Y) with monothiodibenzoylmethane (SBB) is studied by solvent extraction method. EDDA, NTA, EDTA-OH, DPTA-OH, EDTA, methyl-EDTA, GEDTA and DTPA are used as aminopolycarboxylic acid. The reaction rate is determined by the measurements of the radioactivity of 203Hg in the aqueous phase. From the respective dependencies of the rate constant on the concentrations of hydrogen ion, SBB and Y, the formation of the mixed ligand complex was approved in the reaction mechanism. The values of the rate constants and stability constants of Hg-Y are found to be correlated each other with a few exceptions such as the cases of EDTA-OH and DPTA-OH, and the rate determining step is considered to be involved in the step of the dissociation of aminopolycarboxylic acid. The usefulness of the solvent extraction method for the kinetic study of complex formation was proved through the result presented here.
Databáze:	OpenAIRE
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